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diabetes
heart disease
atherosclerosis
Monckeberg

Part I The Significance of Monckeberg Atherosclerosis

broken foot

Monckeberg atherosclerosis is different from typical atherosclerosis and most commonly is associated with adult onset diabetes mellitus. It affects the medial layer of the artery while typical atherosclerosis affects the intimal layer. Monckeberg is typically more systemic (if you have it anywhere you have it everywhere) while typical atherosclerosis tends to occur around areas of increased turbulence of blood flow, usually branch points.


old adage from medical school

50% of people dying with their first heart attack with no known previous history of heart disease will have diabetes.

Monckeberg Atherosclerosis (Medial Artery Calcification)
stiff pipes

Two views of my right foot from July 1995. The normal non-inverted view (upper view) shows the fracture of the proximal fifth metatarsal and if you look carefully between the first and second metatarsals you can see what looks like a small white donut with tracks leading away from it.

broken foot

The inverted and enlarged view below shows the same except now the white is black and is marked by the black x's. This is calcification of the medium and small arteries of my foot of the Monckeberg variety. This calcification does not block the artery but does result in a very stiff artery. These calcified stiff arteries have reduced compliance (the ability to dilate or constrict when they need to).



Typical (intimal) atherosclerosis vs
Monckeberg atherosclerosis (medial layer)

broken foot

The two views below are from a Finnish study referenced below. The image on the right shows very discrete and uniform calcification of the artery in the thigh (superficial femoral artery) while the image on the left shows the irregular clumpy calcification of typical atherosclerosis of the non-Monckeberg variety. As is clearly evident two different appearances, two different processes. The process on the left affects the intimal layer of the artery (typical atherosclerosis) while the one on the right affects the medial layer of the artery. Arteries have three layers, intima, media and adventia.(from the inside out )

>>>beginning of Finnish study published in 1996

Medial Artery Calcification

A Neglected Harbinger of Cardiovascular Complications in Non–Insulin-Dependent Diabetes Mellitus Seppo Lehto; Leo Niskanen; Matti Suhonen; Tapani Rönnemaa; Markku Laakso

the Departments of Medicine (S.L., L.N., M.L.) and Radiology (M.S.), Kuopio University Hospital, Kuopio; the Department of Medicine (T.R.), Turku University Hospital, Turku; and the Research and Development Centre (T.R.), Social Insurance Institution, Turku, Finland.

broken foot

Correspondence to Markku Laakso, MD, Professor, Department of Medicine, University of Kuopio, SF-70210 Kuopio, Finland. E-mail Markku.Laakso@uku.fi.

Abstract

Medial artery calcification (MAC) is a nonobstructive condition leading to reduced arterial compliance that is commonly considered as a nonsignificant finding. The aim of our study was to investigate the predictive value of MAC in relation to 7-year cardiovascular mortality, coronary heart disease (CHD) events, stroke, and lower extremity amputation in 1059 patients (581 men and 478 women) with non–insulin-dependent diabetes mellitus (NIDDM). At baseline radiologically detectable MAC in femoral arteries was found in 439 patients (41.5%) and intimal-type calcification in 310 diabetic patients (29.3%). The mean fasting plasma glucose at baseline was somewhat higher in women and the duration of diabetes somewhat longer in patients with MAC than in those without, but otherwise the presence of MAC was unrelated to conventional cardiovascular risk factors. During the follow-up 305 diabetic patients died: 208 from cardiovascular disease, 158 from CHD, and 34 from stroke. Furthermore, 58 NIDDM patients underwent their first lower extremity amputation. MAC was a strong independent predictor of total (risk factor–adjusted odds ratio and 95% confidence interval: 1.6; 1.2, 2.2), cardiovascular (1.6; 1.1, 2.2), and CHD (1.5; 1.0, 2.2) mortality, and it was also a significant predictor of future CHD events (fatal or nonfatal myocardial infarction), stroke, and amputation. This relationship was observed regardless of glycemic control and known duration of NIDDM. MAC is a strong marker of future cardiovascular events in NIDDM unrelated to cardiovascular risk factors, supporting the hypothesis that reduced arterial elasticity could lead to clinical manifestations of diabetic macroangiopathy.

>>>end of Finnish Study

two types of atherosclerosis
two types of angina

These two different types of atherosclerosis yield two different patterns of angina (chest pain related to myocardial ischemia). While both are fixed lesions the intimal type usually doesn't become known until it is reducing blood supply sixty percent or more. Once this happens there is no other way for the blood to get to the heart muscle except for collateral arteries which may or may not be present. Once symptoms begin, they usually do not go away. However as I have personally experienced with Monckeberg atherosclerosis, the symptoms can be extremely severe one day and completely gone the next.

severe angina on the run

I have had to stop a run only once in the first mile in over thirty years of running. This happened one day as I headed out the canal path in Broad Ripple circa June 1994. The angina started in my neck and chin then the left arm, next the right arm and then the whole upper-half of my body. After about a half-mile I had to walk. I would walk for a while and then be able to run for a while, then I would have to walk again. This went on for about the first three miles of a six mile run. The day before I had eaten a vegan but fat filled scone in Bloomington. The rest of that day after recovering from the severe angina, I avoided eating any fat especially trans-fat. The next day I ran normally with no chest pain. I have had to become very aware of trans-fats as now even the slightest amount of them will give me angina. This is because the trans-fat molecules are either just too big or too solid to pass through the Monckeberg stiffened arteries and arterioles. These molecules can block the artery just like any solid embolus. This a form of fat embolization / microembolization.

Conclusion

As is clearly evident from the Finnish study and my own personal experience, Monckeberg Medial Artery Sclerosis is NOT to be ignored and is clearly associated with ischemic heart disease including sudden death.

Thanks for your time and your attention.
Copyright © John Mericle M.D. D.A.B.R. 2000-2012 All Rights Reserved

Protected by Copyscape Online Plagiarism Tool


Weight loss is easy!



The Ironman ...
well maybe not easy!



How To

Be Slim ... Be Healthy ... Be Fast



If you think you can't lose weight and eat well
-you haven't tried the MericleDiet!

How do you lose weight (40 pounds) and keep it off (38 years) without hunger while you reduce your risk for serious illness and improve your health and fitness?

Finally ... Free Your Mind From The Constant Concern Over What You Eat And What You Weigh!

The MericleDiet

  • Lose Weight With No Hunger
  • Eat Well Everyday
  • Stop Wasting Time Worrying About What You Eat
  • Make Weight Control and Wellness An Integral Part of Your Lifestyle
  • Lower Your Food Costs
  • Improve Your Health and Lower Your Risk of Disease
  • Make Exercise "The Icing on the Cake of Proper Nutrition"
  • Still Enjoy That Occasional Meal Out
  • Learn Food Preparation Techniques That Will Last Your Lifetime and Will Improve Like Wine
  • Enjoy Real Variety of Both Raw and Cooked Foods
  • Lower Your Bad Cholesterol Without Dangerous Drugs
  • Learn The Basics of The Metabolism of Weight Control
  • Put Your Food, Meals and Weight Control All On Autopilot

I have lived with this diet now for over thirty-eight years. It has controlled my adult onset diabetes mellitus and its associated heart disease and retinal disease. My meals are better than ever now and I enjoy my food as much as anyone and don't limit how much I eat. I haven't worried about my weight since sometime in May 1977.

The MericleDiet

Enjoy Safe and Permanent Weight Loss While You Reduce Your Risk for Disease. The MericleDiet is the Easy Transition to a Healthy Vegetarian Sugar-Free 100% Organic Diet.

The Best Diet for Cancer Prevention!

This diet is the ONLY Diet Today that Makes it easy to be 100% Sugar-Free and 100% Organic. Nothing slows your Immune System like Sugar and Nothing Cripples your Immune System like the Pesticides, Hormones and Antibiotics used in commercial food production.

Nothing will make your Immune System happier.


The Best Diet for Coronary Artery Disease Prevention!

This is the Only Diet that is 100% Meat, Dairy and Sugar FREE! The association between meat ingestion and demonstrable coronary artery disease has been known for years. Restricting all forms of animal protein and sugar will help to keep your "coronary arteries and arterioles clean and compliant."

Your Heart Will Love You!


The Best Diet for Prevention of Stroke!

By completely avoiding the Causes (Meat and Dairy) of Atherosclerotic Plaque Buildup in the Carotid Bifurcation you significantly reduce your risk for Stroke!

Your Brain (Woody Allen's second favorite organ) will reward you with many more years of creative thought and locomotion!



The Best Diet for Prevention and Control of Adult Onset Diabetes!

Adult Onset Diabetes Mellitus (a polite and confusing term for Sugar Toxicity) is now epidemic. The prediction that 10% of teenagers will get this slowly crippling and killing disease by age twenty, is not surprising in this day where sugar consumption is also epidemic and at record levels. This is the only diet that makes it easy to transition away from sugar all together. Believe me, I know, I have adult onset diabetes mellitus and have controlled it with the 100% Sugar-Free MericleDiet for the past twelve years.

Your arteries will remain compliant and will thank you
by allowing good blood flow to all your favorite organs!


The Best Diet for Prevention of Osteoporosis!

That the continued consumption of meat and diary in this country is the
Cause of the Epidemic of Osteoporosis isn't even a subject of debate. This
information has been known for over twenty-five years. The MericleDiet makes
the transition away from meat and dairy easier than you would ever believe.
Believe me, we don't suffer on this diet.

Your bones will remain strong, not fracture as easily
and you will not "Shrink" as you get older.

Stop!

Are you tired of dieting?

Are you tired of worrying about your weight?

Are you tired of worrying about cancer, heart disease and stroke?

Do you have adult onset diabetes?

Are you worried about osteoporosis?



Ask Yourself?

Would I rather not worry about all this?

Do you look as good as you could?

Do you want to eat a healthier diet but don't know how?

Are you confused about what to eat and what is a true carbohydrate?

Do you exercise but don't seem to lose weight?



I think we all have felt this way and asked many of these same questions. This physician certainly has.

Back to 1977 University Medical Center Tucson, Arizona

At 34 years old I was in my fourth year of Diagnostic Radiology training and had a physical exam for a life insurance policy. For the first time in my life my blood pressure was elevated to borderline abnormal at 140/90 up from 118/78. I was weighing a "robust" 175 pounds on a 5'6" frame and my waist had burgeoned from 32 inches to 37 inches. I had already had my first angina at age 30.

Not really feeling all that great!

I didn't feel very good and was starting to have headaches probably related to the elevated blood pressure. I would eat large meals and still be hungry. I would get hypoglycemic usually about two in the afternoon and usually eat something sweet. Actually I found it difficult to feel good when I was that overweight. As I look back now I recognize the early signs of adult onset diabetes mellitus. I also knew that I was not going have the usual diagnostic barrage of studies for hypertension that I as a resident was administering to patients routinely.

Enter Dr. Kai Haber

Dr. Haber was one of the younger staff in the Department of Radiology. He had just started running and had stopped eating most meat and dairy products. Realizing even then that I was destined for some not so pleasant days ahead if I did not change my lifestyle, I started running and stopped eating meat and dairy. One early afternoon around three pm I was walking out to go for a run when Dr. Haber asked where I was going. Expecting the worst like get back in the department you lowly resident Dr. Haber surprised me. He said, "John, that is the most important thing you can do for yourself right now." The rest is history and I am in the 37th year of my daily running streak -four miles or thirty minutes every day, not to mention 29 Marathons (PR 2:45) and three Hawaii Ironman Competitions.

The School of "Lifestyle Disease" Hard Knocks.

Some almost 18 years later ... 1995.

I would often find myself thinking over these years that I had "pretty much" figured out most things relating to diet and health. Then I would be faced with yet another problem relating either to my health or the health of some member of my family. I would then have to further refine my diet. In fact I learned very quickly that I will never know all there is to know about the relationship between diet and health. In January 1995 my ex-wife finds a mass in her left breast that by ultrasound is malignant. She had continued to eat a fair amount of cheese, much the same as Linda McCartney. Just when I thought everything was right, in July 1997, I find adult onset diabetes in myself and realize that my sugar ingestion (for me it was Pepsi) is severely damaging my vascular system.

Why Reinvent the Wheel?

Why wait until you have demonstrated proof of disease in yourself. Why wait until you are overweight and hypertensive. The MericleDiet is the product of 29 plus years of the school of hard disease knocks. This food preparation system can help keep you stay clear of these disasters and will give you a base to start developing your own refinements and additions to this system of health. By purchasing the MericleDiet you will be kept current of any new developments or refinements in the future. We also encourage all who purchase the diets to email us with any refinements, suggestions or additions of their own so that we all can learn from each other.



The MericleDiet Food Preparation System.

The MericleDiet allows you to lose weight safely, permanently and without hunger while you reduce your chances for coronary artery disease, cancer and stroke.

Want to eat a healthier diet but don't know where to start?

By preparing basic food groups in quantity sufficient for a week you can feed yourself and your family a great tasting and healthy organic whole food diet -on short notice. If you and your family only eat one meal a day from this diet it will begin to fine tune your body. You will find that your cravings for what is not good for you like sugar, meat and dairy will gradually diminish. You will feel better and look better while you lose weight. You will not have to starve yourself and will eat as much as you like of healthy foods.

Table of Contents.

  • Introduction including Why Organic.
  • Potatoes
  • Beans
  • Soups
  • Gravy
  • Bean Burritos
  • Tacos
  • Enchiladas
  • Pasta
  • Tofu and Tempeh
  • Whole Grain Rice
  • Fruits and Nuts
  • Fresh Produce, Salad and Salad Dressings.
  • Carbohydrate Confusion
  • Insulin and Glucagon
  • Recommended Reading

Throw away your scales.

You will not have to worry about your weight. If you start to put on a few pounds you will know it immediately and just decrease your food consumption and cut back on eating anything that is not so good for you. This diet is so powerful that as long as you get one good meal a day, you will be able to have that occasional dietary indiscretion that we all do.


Learn the Secrets of how to Look Better and Feel Better for Life and Save Money.


Advantages of The MericleDiet.

Cook on Sunday and eat well all week.

By doing all of your "prep" cooking and food preparation on Sunday you reduce the amount of time you have to spend preparing tasty Whole Food meals during the week.

Makes great tasting Whole Food meals available on short notice.

With a well stocked refrigerator full of basic Whole Food foods you will never have to worry about what to cook for yourself or your family. Take out several short-term preserved foods and combine in any fashion you like. Voila ... a great tasting, healthy Whole Food meal.

No increased risk of disease, actually you reduce your chance for disease on this diet.

As is currently being proven some of the latest diet fads actually increase your risk for coronary disease, cancer, stroke and osteoporosis. The MericleDiet will reduce your risk for all these diseases and also will increase your energy and general feeling of well being.

Lower food costs.

Even though we recommend organic foods your overall cost of eating on this diet will decrease considerably since you will not be eating a lot of expensive processed and packaged food items.

Exercise.

You don't have to exercise on this diet. While we do recommend that you exercise -it is not to lose weight. Exercise is good for the immune system and your mental well being but is not an integral part of this weight loss program.

Forget worrying about your weight for good.

You won't have to worry about your weight all the time. You will look good and feel good. There are too many other concerns in this life to worry about your weight.

Creative Cooking.

By learning the basic cooking principles in the MericleDiet you leave behind the confining world of recipes mostly based around meat and dairy. You will never eat exactly the same meal twice and your meal preparation becomes an wondrous exercise in creative cooking, depending on what is short term stored in your refrigerator.

Healthy great tasting Mexican food.

Mexican food is not difficult to prepare and once you learn to make good beans and get good tortillas you can eat some very tasty Mexican dishes that are made with organic beans and organic tortillas.

You avoid commercial food.

Commercially grown food today is at least nearly if not completely nutritionally bereft. Besides being nutritionally bereft most if not all of it is loaded with either pesticides or sugar or both.






Warm or cold whole grain brown
rice makes a nice addition to any salad.




What's in it for you?

This is a very serious question.

  • Look better.
  • Feel better.
  • Better health.
  • Better work and better play.
  • Weight loss without hunger.
  • Decreased food costs.
  • Decreased health care costs.
  • Decreased morbidity and mortality from the common lifestyle diseases of today: coronary artery disease, cancer and stroke.

Why should you care?

Another great question. While you are healthy and actually perceive no real health problems, you may not care. However, there comes a time in most people's lives where they are faced with serious health problems that can significantly compromise their quality of life. The MericleDiet is not as much about life and death as it is about "Quality of Life." Putting your ego aside can be tough but when your health and quality of life hang in the balance most intelligent people will in time do all they can to be as healthy as they can. The MericleDiet is a very "clear" path to improving your health as much as you can through simple dietary manipulation.


Why is this woman starving?

Demonstration of the relationship
between malnourishment and obesity.






The "Incomplete food cycle."

You eat incomplete foods. You body is hungry as soon as your stomach empties. You eat more incomplete foods trying to satisfy this hunger. This hunger cannot be satisfied with incomplete foods so you continue eating more incomplete foods. Never satisfied and always hungry you end up overweight with high insulin levels all day and usually all night long. Before long you are really overweight and sick. Your quality of life plummets.

This woman is starving and overweight because:

  • She is buying heavily processed and sugared packaged foods.
  • There is little if any real nutrition is all of the combined grocery stores of the food industry behemoths.
  • This woman has very high insulin levels.
  • High insulin levels are associated with all of today's "diseases of affluence: coronary artery disease, cancer and stroke."
  • One of the strongest relationships that exists today is the relationship between nutrition and disease.

Order The Complete Revised MericleDiet Today for Only $47

Is your health and mealtime enjoyment worth $47?

The cost of MericleDiet is $47.

The cost of a combined medical/nutritional consult here in Tucson today is $395 for the first visit and $195 for the second visit.

The cost of health insurance today is $9950 for a family of four, up 59% in the last three years. The cost for an individual is $3695.
These figures are from the Kaiser Family Foundation.

The cost of Coronary Cinangiography is $2500.00+.

The cost of your average cancer therapy is in most cases well over $2500.00 / month.
The cost of a stroke and the needed care is well over $25000.00.

A mere $47 will significantly reduce your chances of having to pay big dollars for your health -not to mention reducing your chances of ever getting sick from one of the big three killers.

Learn how to really play the odds of staying healthy.





Act Now and get the Complete Revised MericleDiet for only $47! One Time Charge for Life!

Ordering the MericleDiet e-book is simple, safe and secure on the Clickbank site. Simply click on the "Order Safely Online" button.






60 Day No Questions Guarantee

If you are not completely satisfied you can obtain a full refund of the purchase price, no questions asked for 60 days following the date of your purchase.



The e-books are in pdf format and require Adobe Reader which can be downloaded from Adobe.com for free.

Thank you for visiting the MericleDiet.

John Mericle M.D. D.A.B.R.

P.S.

Some of the things you won't have with the MericleDiet!

  • Recipes with sugar
  • You will not go hungry.
  • Complicated recipes to follow
  • Monthly Meetings
  • Costly programs with recurring charges
  • Counting Points
  • Dangerous Pills or Drugs
  • No Surgery!
  • No Worry about your weight!
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Unsolicited Endorsement

Just wanted you to know that I appreciate all the helpful tips you send from time to time. Thank you again and keep doing the best you can to 'save lives.'

Nathalee Dixon
Kingston, Jamaica


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Glucagon and Weight Loss

Previous Newsletters

The Exercise Myth
Olive Oil -Chest Pain In A Bottle
Six Simple Things To Reduce Your Risk of Diabetes
Diabetes Heart Disease Monckeberg
Vitamin C Sugar Competitive Inhibition
How To Read and Evaluate Current Literature, Diet Plan Claims and Information
Organic Foods Your Health Planet Earth
The Dangers of High Fructose Corn Syrup
How Fasting Affects Your Metabolism
The Fallacy of Multiple Small Feedings
The Order of Energy Utilization
14 Simple Things You Can Do to Reduce Your Risk for Breast Cancer
Essential Fatty Acids
Twelve Simple Changes to Lower Your Blood Pressure
Twelve Simple Changes to Lower Your Blood Pressure Part II
Angina Doesn't Care If You Are Half-Right
Aspartame (Nutrasweet) -More Dangerous Than High Fructose Corn Syrup
Five Serious Dangers of Low-Carb Diets
Stevia -A Safe Sweetener!
Brown Sugar Is Not Brown Rice
Honey and Meli Maenomenon
What Really Causes Osteoporosis
Proper Nutrition -No Weight Loss Program Can Succeed Without It!
Fifteen Diet Secrets Revealed!
Medical Bankruptcy -The Cost of Illness!
Rugrat -The Dangers of New Carpet
Mesothelioma
Macular Degeneration
Gray Hair Your Liver and He Shou Wu
Four Steps of Hunger Control
Glucagon -Mother Nature's Answer to Aging!
Your Stomach Knows Best
Chunky Cole Slaw
How to Prevent Hypoglycemia(Low Blood Sugar)

EzineArticles.com Platinum Author

Unsolicited Endorsement

Really enjoy the newsletter. Find it very informing so thank you. Gave up drinking milk last year after reading your article! Feel much healthier as a result.

Wendy Goodwin
UK


Unsolicited Endorsement

I appreciate the information. I learned this, not in the same depth, 15 years ago and needed to be reminded how detrimental this is. Knowledge is power.

Lee Ketcham
Cincinnati, Ohio


Unsolicited Endorsement

"I love this diet because it takes so little time to prepare."

Referring to episodes of hypoglycemia:

"I really like this diet because I do believe the episodes of hypoglycemia are caused by the lo-carb approach, which is wrong for me."

From a latter letter:

"...and the drastic cut-down on sweets, and the diet (I would say I practice most of the time) must be helping......because I am not usually hungry, and have had NO episodes of hypoglycemia ..."

Diane Newman R.N. B.S.N. Hamilton, Ohio


Endorsement

The Mericle Diet and Me

I have been reading about diet and health since 1986, but The MericleDiet has definitely helped me the most. After following Dr. Mericle's suggestions for over 15 months, I can truthfully say I will never stray from his program. One of the unseen benefits has been the reduction of blood pressure medicine I take. Although I have never been a big consumer of sugar, I now consume even less since I now understand the importance of keeping your insulin levels low. I am now able to keep my blood pressure at an optimal level with half the medication of my pre-MericleDiet days. And, the ease of this program! I always have something yummy and ready to eat! For the first time in my adult life I no longer suffer, and I do mean suffer, from the yo-yo syndrome!

This is absolutely the best program for me and my family...

Kay McIlroy
Colorado Springs


Unsolicited Endorsement

Hi Doctor , I congratulate you on your mailings , lately about sugars , for sure I will reduce mine and kids use and abuse of sugars , , please can you explain about real honey and I mean real one , We buy directly from a producer that got plenty of beehives . Thanks very much and keep up with the good work.

E.B.
Uruguay



Unsolicited Endorsement

I had the best dinner tonight, I sauteed some onions and fresh garlic in my wok, then put it on the side then sauteed a red bell pepper, tofu, and broccoli, ( put that on the side) then took some cooked brown rice and fried it up adding water and soy sauce, then added it all together, then made a fresh salad with red onions, spinach leaves,romaine lettuce. That was the best meal I've had in sooooooo long!!!!! mcdonalds ( or any restaurant , for that matter)couldn't touch that meal !!!!! Thanks Yolanda

From another letter:

The best part of this diet is that when I'm finished eating I don't feel guilty, and I don't feel blah, I feel good, nooo I feel GREAT !!!!! for lunch I had potatoes( the way you said to cook them ) and some corn tortillas. Thanks Yolanda

Yolanda Highsmith
Sulphur, Louisiana